Kyle Edmund vs. (13) Richard Gasquet. Gasquet if he is healthy. Nothing else really needs to be said. Gasquet in 4.

(9) Jo-Wilfried Tsonga vs. (Q) Guido Andreozzi. A Tsonga vs. Marin Cilic fourth-rounder would be intriguing. If someone stops it from happening, it won’t be Andreozzi. Tsonga in 3.

James Duckworth vs. Robin Haase. Few matchups scream five-setter quite like Duckworth vs. Haase. The Dutchman generally plays well in New York, so he’s the pick. Haase in 5.

Vasek Pospisil vs. (LL) Jozef Kovalik. Can Pospisil beat anyone in singles right now? We’re about to find out if even a lucky loser is too tough of a task. Kovalik in 4.

Yoshihito Nishioka vs. (23) Kevin Anderson. The Anderson of 2015 (upset Andy Murray in the fourth round) ain’t walkin’ through that door. But he’s still better than Nishioka. Anderson in 4.

(26) Jack Sock vs. Taylor Fritz. There’s a good chance the American will take this one. Sock in 4.

(Q) Mischa Zverev vs. Pierre-Hugues Herbert. The younger Zverev would probably win it. As for the older one, at least he got into the main draw. Herbert in 5.

Rogerio Dutra Silva vs. (7) Marin Cilic. To be honest, the tournament would be better off if guys like Dutra Silva gave up their spots in the main draw to the next players on the entry list. Cilic in 3.

(4) Rafael Nadal vs. Denis Istomin: Their first two meetings were good (including at the 2010 U.S. Open). Their two most recent meetings were not. Nadal in 3.

Thomaz Bellucci vs. Andrey Kuznetsov: A Bellucci-Nadal rematch of their Rio Olympics three-setter could be fun. Kuznetsov is not playing like he will be the one to stop the Brazilian. Bellucci in 3.

Brian Baker vs. Federico Delbonis. Heart says Baker. Head says Delbonis. Head usually wins, but not in Baker’s case; he’s too much of a sentimental favorite. Baker in 4.

Guillermo Garcia-Lopez vs. (15) Roberto Bautista Agut: Bad news for RBA: he lost the Winston-Salem singles final on Saturday and looked gassed while doing so. Good news for RBA: GGL also had to stick around in Winston-Salem all week as he won the doubles title. Bautista Agut in 4.

(10) Gael Monfils vs. Gilles Muller. Monfils took down Ivo Karlovic in Washington, D.C. and Milos Raonic in Toronto. He knows what he’s doing against big servers: righties or lefties. Monfils in 4.

Dudi Sela vs. (18) Pablo Cuevas. There will likely be several instances of the Israeli supporters getting under Cuevas’ skin. Unfortunately for Sela, what happens between the lines will be more straightforward. Cuevas in 3.

Marcos Baghdatis vs. Facundo Bagnis. Bag should clinch it. Baghdatis in 3.