Cyclobenzaprine: MedlinePlus Drug Information

Cyclobenzaprine: MedlinePlus Drug Information

First, 10 of the 14 trials had evidence that blinding may not have been effective; patients receiving cyclobenzaprine had more adverse effects than those treated with placebo. The most common adverse effects were sedation, dry mouth, fatigue, and dizziness (Table 3). Inadequate blinding has been believed to be responsible for bias in previous trials suggesting benefit from ascorbic acid55 and zinc56 for the common cold. Our results may be particularly prone to this bias, since most outcomes are based on physician rather than patient reports of symptom improvement.

Research is lacking on whether or not antispasmodics are more effective in treating muscle pain and spasms than NSAIDs or acetaminophen. Antispasmodics have more side effects than NSAIDs and acetaminophen, so it’s important to talk to your healthcare provider about the benefits and risks of taking these medications. Antispastic medications are effective in treating spasticity, but high doses can lead to unwanted side effects. Other treatments can help with spasticity as well, including physical therapy and Botox® injections.

Although all skeletal muscle relaxants should be used with caution in older patients, diazepam especially should be avoided in older patients or in patients with significant cognitive or hepatic impairment. Importance Low back pain (LBP) is responsible for more than 2.5 million visits to US emergency departments (EDs) annually. These patients are usually treated with nonsteroidal anti-inflammatory drugs, acetaminophen, opioids, or skeletal muscle relaxants, often in combination. Muscle relaxers (also called muscle relaxants) are prescription medications that affect muscle function. Healthcare providers prescribe them to treat several symptoms, such as muscle spasms, spasticity and musculoskeletal pain. Cyclobenzaprine is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries.

• In light of these findings, therapy with FLEXERIL in the elderly should be initiated with a 5 mg dose and titrated slowly upward.
• Because of limited comparable effectiveness data, choice of agent should be based on side-effect profile, patient preference, abuse potential, and possible drug interactions.
• However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist.

The analysis of the primary outcome consisted of 3 pairwise comparisons of the change in RMDQ between baseline at ED discharge and 1 week later, reported with 98.3% CI. Exploratory outcomes were not adjusted for multiple comparisons. These are reported as between-group differences with 95% CIs or difference between medians with 95% CIs. The number needed to treat (NNT) is presented with a 95% CI when naproxen + active medication resulted https://flexeril.live in a statistically significant improvement in outcome compared with naproxen + placebo. The number needed to harm (NNH) is presented with a 95% CI when naproxen + active medication resulted in a statistically significant increase in adverse events compared with naproxen + placebo. Providers mainly prescribe antispasmodic skeletal muscle relaxants for musculoskeletal and myofascial pain, especially lower back pain, and muscle spasms.

BACK AND NECK PAIN

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Older adults may be more sensitive to the effects of this medicine. For a thorough understanding of potential side effects, please consult a physician.

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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 3 Sep 2023), Cerner Multum™ (updated 28 Aug 2023), ASHP (updated 10 Aug 2023) and others. Many patients won’t benefit from adding cyclobenzaprine to their ibuprofen prescription (or vice versa). Additionally, the combination can increase the patient’s odds of showing CNS side effects. All in all, you’ll want to stop cyclobenzaprine in 2–3 weeks and rely on physical therapy sessions to control the pain in the long term.

Drug Interactions

It is used in conjunction with rest, physical therapy, and other treatments to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries. It belongs to a class of drugs known as skeletal muscle relaxants. It works by relaxing the muscles by acting on the brain and nervous system.

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The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol and metaxalone are less sedating, although effectiveness evidence is limited. Adverse effects, particularly dizziness and drowsiness, are consistently reported with all skeletal muscle relaxants. The potential adverse effects should be communicated clearly to the patient.

Are muscle relaxers effective?

At oral doses of up to 10 times the human dose, cyclobenzaprine did not adversely affect the reproductive performance or fertility of male or female rats. Cyclobenzaprine did not demonstrate mutagenic activity in the male mouse at dose levels of up to 20 times the human dose. Pharmacologic similarities among the tricyclic drugs require that certain withdrawal symptoms be considered when FLEXERIL is administered, even though they have not been reported to occur with this drug. Abrupt cessation of treatment after prolonged administration rarely may produce nausea, headache, and malaise.

Some people may not feel drowsiness at all, while others may feel it intensely. Other common Flexeril side effects include nausea, dry mouth, and dizziness. If you forget a dose, contact your doctor or pharmacist as soon as possible to arrange for a new dosing schedule.